Vitex rotundifolia fractions induce apoptosis in human breast cancer cell line ... Padhi MM, Babu R. A review of the important chemical constituents and medicinal uses of Vitex genus. It has been used for medicinal purposes throughout its native range. Makino, Vitex trifolia var. The potent anti-inflammatory flavonoids have been discussed below. act as febrifuges, and are widely used for this. Add to Likebox #98876512 - Close up of Vitex rotundifolia seeds. Vitex trifolia and Vitex rotundifolia are deciduous shrubs, which belong to the Verbenaceae family. ovata (Thunb.) Regrowth has been observed by members of the Beach Vitex Task Force. It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. Fifteen flavonoids (121–135) isolated from the twigs of Morus alba and evaluated for their anti-inflammatory activities by examining their ability to inhibit LPS-induced NO production in macrophage RAW 264.7 cells. ha–1. Furan containing androstadiene derivative 10 has been shown to be useful for the therapeutic treatment of inflammatory disorders of the respiratory tract <2002USP2002177581>. It is hardy to zone (UK) 7. All the compounds displayed significant inhibition of LPS-induced NO production in RAW 264.7 cells with the IC50 values ranging from 2.2 to 12.8 μg/mL. The most effective control method explored to date incorporates imazapyr treatments. Briq. are most used; sometimes also roots or fruits. Similar Images . Vitex, or chaste tree (Vitex agnus-castus)—celebrated by women in ancient Greek festivals and on holy days as a symbol of marriage, chastity and fertility—gives contemporary women cause for celebration, too: it can safely and effectively relieve the monthly misery of difficult menstrual cycles. Its leaves are rounded at the tips with green upper surfaces and silver lower surfaces. It is a muscle relaxant and pain relieving herb. The NCSU Arboretum, Amount of calyx fibres in Lamiaceae, relation to calyx structure, phylogeny and ecology, Abietane-type diterpenoids from the fruit of Vitex rotundifolia L-fil, In: A De Candolle Prodromus Systematis Naturalis Regni Vegetabilis, Ecdysteroids from Vitex Species: Distribution and Compilation of Their C-NMR Spectral Data, Effect of Vitex rotundifolia on immediate-type allergic reaction, Constituents of the essential oil of Vitex rotundifolia Linn fil, Koryo, Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu, Notes on some interesting species of Verbenaceae from South India. Plant Produces Flowers Yes [back to top] Flower Characteristics. Species trifolia means with three leaflets. Similarly, compound 182 exhibited excellent COX-2 inhibitory activity with the IC50 value of 9.5 μM [217]. The fruits of Vitex rotundifolia have been used as a folk medicine for the treatment of headache, cold, migraine, eye pain, female hormonal disorders, asthma, chronic bronchitis and gastrointestinal infections, such as diarrhea and bacterial dysentery. After six months, all visible above ground plant parts are removed from the sites so non invasive beach plants can be planted. Vitex rotundifolia has many medicinal uses. Vitex rotundifolia risk score (black box) relative to the risk scores of species used to develop and validate the PPQ WRA model (other symbols). Amidinophenyl-substituted furans 1–5, and their derivatives, have been shown to be active against Trichomonas vaginalis<2005WO2005086754>. J Nat Prod. In Anatolian folk medicine, it is used as a diuretic, digestive, antifungal, and anxiolytic agent. The inclusion complex of bromofuran 8 not only increased the aqueous solubility of the furan compound, but also the dissolution rate <2004JPS197>. The Role of Font Color, Size, and Sale Sign Location in Retail Garden Center Displays, Alkalinity of Irrigation Return Water Influences Nutrient Removal Efficacy of Floating Treatment Wetland Systems. with MIC of 0.5, 1.0 μg/mL on Microsporum gypseum and Trichophyton mentagrophytes, respectively.123,124, Among other phenolic compounds, xanthones and quinones are known for their potent MRSA-inhibitory properties and are therefore considered as lead compounds for synthesizing new antibacterial agents.125–127 Mangostanin (31), a tetraoxygenated xanthone isolated from the fruit of Garcinia cowa, is a strong growth inhibitor against two penicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus with MIC values of 4.0 μg/mL.128, In studies on the compounds of the roots of Cratoxylum formosum, several potent antibacterial xanthones have been isolated. All compounds displayed good inhibition against NO production in induced LPS with a concentration of 10 mM [207]. Because rotundifuran specifically inhibits cholesterol acyltransferase, the isolated compound is effective in lowering blood cholesterol and can be used in the prevention of cardiovascular disease caused by hypercholesterolemia. Both the compounds showed COX-1, COX-2 and 5-LOX inhibitory activity greater than the standard use. The authors would like to thank all of the volunteers who have given of their time and energy to control this invasive plant and prevent further damage to the fragile dune environment. [Google Scholar] 10. University of Hawaii at Manoa, Handbook for Ranking Exotic Plants for Management and Control, Anti-nociceptive and anti-hyperprolactinemin activities of Fructus Viticis and its effective fractions and chemical constituents, Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: its implication for quality control of medicinal plants, Estrogen-like activity of volatile components from Vitex rotundifolia L, Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome, Population Genetic Structure of the Medicinal Plant. College of Tropical Agriculture and Human Resources. Add to Likebox #72156409 - Prescribed medicinal Vitex negundo as herbal medicine over white. 2006), female hormone-related health issues (Hu et al. Vitex rotundifolia in China: Implications for its Use and Conservation, IPNI (The International Plant Names Index), Aryl naphthalenes norlignans from Vitex rotundifolia, Phenylnaphthalene compounds from the subterranean part of Vitex rotundifolia and their antibacterial activity against methicillin-resistant Staphylococcus aureus, Invasive plants on disturbed Korea sand dunes, International Collation of Traditional and Folk Medicine, Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells, Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells, Polymethoxy flavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells, G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil. Fig. It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. Vitex rotundifolia L.f. Family Name: Lamiaceae (Labiatae) Synonyms: Vitex trifolia var. Technical Contribution No. Eupafolin (141) isolated from the methanolic extract of Chinese plant Phyla nodiflora displayed significant anti-inflammatory action in different bioassays. All the isolates were subjected for their anti-inflammatory potential in the supernatant media of human PBMCs by measuring the levels of IL-1β, IL-6, TNF-α and PGE2 stimulated by phytohaemagglutinin (PHA). Furan containing aminoalcohol 6 belongs to a class of pharmaceutical compounds for use as immunosuppressants for the treatment and/or prevention of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, psoriasis vulgaris, atopis cermatities, insulin-dependent diabetes, glomerulonephritis, and graft rejection. The proliferation of each tumor cell line was significantly inhibited (IC50 values from 0.2 to 1.8 μg ml−1) during the continuous exposure of the tumor cells to the tanshinone compounds for 48 h. THF derivatives have also been found to be components of many pharmaceutical compounds. The flavonoids (171–174), hispidulin (171), nepetin (172), apigenin (173), and luteolin (174) were isolated from the aerial parts of methanol extract from the plant Onopordum acanthium. (Verbenaceae) is a small tree or shrub which is widely distributed along the Anatolian coast line and is used in the treatment of premenstrual problems and hyperprolactinemia. Also known as chaste tree or chasteberry, it's often taken as a remedy for women's health problems. Germination should occur within 3 to 6 months, although, there have been some instances where seeds have germinated earlier. Agronomy Department, Institute of Food and Agricultural Sciences, University of Florida, Tracheospasmolytic activity of Viteosin-A and Vitexcarpin isolated from Vitex trifolia, An evaluation of the invasive potential of beach Vitex (Vitex rotundifolia), The Belle W. Baruch Institute of Coastal Ecology and Forest Science, Clemson University, The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action, The families and genera of vascular plants, Norfolk works to rid Willoughby Spit of damaging plant, Hawaiian Native Plant Propagation Database (HNPPD). Monte Carlo simulation results (N=5,000) for uncertainty around the risk scores for Vitex rotundifoliaa. Keay, ... P.W. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Vitex Negundo is a medicinal herb. BV may also be used in the treatment of allergies, antibiotic-resistant bacteria, and pain. Vitex Negundo is a medicinal herb. Imazapyr effectively controlled BV in these studies whether applied either as a cut stem treatment or as a foliar spray. 2000), and pain (Hu et al. The present review aims to compile medicinal values of Vitex … Cooperative Science Program, Miscellaneous notes on Hawaiian plants – 3. Medicinal Plants Medicinal plants and their uses (medicinal herbs) Home » Medicinal and Aromatic Plants » Round Leaf Chastetree, Beach Vitex. National Germplasm Resources Laboratory, Beltsville, Maryland. Crit, A computer-assisted approach for chemotaxonomic studies – diterpenes in Lamiaceae, Constituents of Vitex rotundifolia L. fil, Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS), Didynamia Angiospermia “Flora des Filipinas Sequn el Sistema sexual de Linneo”, Toward a phylogenetic classification of the Labiatae, Genera of Labiatae: status and classification, Advances in Labiatae Science., Kew: Royal Botanic Gardens, De Plantis in Expeditione Romanzoffiana et in Herbariis Regiis Observatis disserere pergitur, Growing characteristics and propagation of Vitex rotundifolia for development of rehabilitation plant in seaboard area, Korean Journal of Environment and Ecology, Vitex agnus-castus L.: (1) A review of its traditional and modern therapeutic use; (2) Current use from a survey of practitioners, Notes on the systematy and distribution of Malayan phanerogams III, Allelopathic potential of Eupatorium maximiliani Schrad. Casticin, a flavonoid found in extracts of BV fruits, has demonstrated an ability to inhibit growth of human cancer cells. The seeds are difficult to remove from the fruit, but the entire fruit can be planted. Tax, “Kudzu of the beach” threatens Carolina Dunes, Engineer Update 28(2) U. S. Army Corps of Engineers, Scary species, superlative sites: assessing weed risk in New Zealand's protected natural areas, Biology and control of beach vitex and common reed, United States Department of Agriculture (USDA), USDA, ARS, National Genetic Resources Program, Germplasm Resources Information Network - (GRIN) [Online Database]. The inhibition in the production of ROS was measured from N-formylmethionyl-leucyl-phenylalanine)-stimulated neutrophils (f-MLP). It is a muscle relaxant and pain relieving herb. Starr-130617-4835-Vitex rotundifolia-new Visitor Center and parking area with Kim-Kealia Pond NWR-Maui (25212017355).jpg 3,648 × 2,736; 2.34 MB The botany of Captain Beechey's voyage; comprising an acount of the plants collected by Messrs. Lay and Collie, and other officers of the expedition, during the voyage to the Pacific and Behring's (20405680825).jpg 2,628 × 3,517; 788 KB Moreover, compound 168 exhibited greater selectivity against COX-2 than reference compound. The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Names of Vitex Trifolia in various languages of the world are also given. 2006), female hormone-related health issues (Hu et al. List of various diseases cured by Vitex Trifolia. In 5-LOX inhibitory activity, compounds 161, 163, 164, 165, 166, and 167 showed excellent inhibition at concentration of 20 μM. Xanthone V1 (32) is active against all the tested pathogens including Staphylococcus aureus with a MIC of 1.1 μg/mL.129 Another compound from this chemical class that shows excellent antibacterial activity on MRSA Staphylococcus aureus (MIC = 4 μg/mL) is nigrolinea xanthone N (33), which is isolated from the leaves of Garcinia nigrolineata.130, A preliminary screening of xanthones containing natural sources for antibacterial activity specifically against Pseudomonas aeruginosa results in the isolation of several xanthones from native Thai plant Cratoxylum cochinchinense, which has long been used as a folk remedy for treatment of ulcers, fever, and coughs. Medicinal Plants in Papua New Guinea Publication Author Publisher World Health Organisation Year 2009 ISBN 978-92-9061-249-0 Description Traditional medicinal uses of 126 species from Papua New Guinea, including information on any modern research into the plants. by Sunil and co-works in 1984.2 In 2001, Zhao and coworkers obtained dendroflorin (1) from D. densiflorum and revised its structure.3 A structural related nobilone (2) was isolated from 60% ethanol extract of the stems of Dendrobium nobile by Yao and coworkers in 2006.4 Both 1 and 2 displayed higher antioxidant activity than vitamin C in the ORAC assay, while dendroflorin (1) have a good performance in antioxidant activity higher than or equivalent to vitamin C in the DPPH assay. Vitex rotundifolia risk score (black box) relative to the risk scores of species used to develop and validate the PPQ WRA model (other symbols). The potency of flavonoids has been explained in many mechanisms of action, such as antioxidant activity, inhibition of enzymes and production of several pro-inflammatory entities [203,204]. Generally homeopathic medicines have a wide range of possible uses, and it is often considered on a person-by-person basis. One of the objectives of WHO monographs is to provide a model that will support countries in developing their own na-tional or regional monographs on medicinal plants or national formular-ies on herbal medicines. (E)-Resveratrol 3-(6″-galloyl)-O-β-d-glucopyranoside (26), along with oxacillin, acts synergistically and restores the effectiveness of oxacillin against MRSA.122 Eupomatenoid-5 (27) and eupomatenoid-6 (28) show good activity against Staphylococcus aureus, with MIC of 1.56, 3.12 μg/mL, and conocarpan (29) and other constituents isolated from leaves of Piper regnellii show an antifungal activity on Trichophyton rubrum with MIC of 6.2 μg/mL. Monte Carlo simulation results (N=5,000) for uncertainty around the risk scores for Vitex rotundifoliaa. Vitex agnus-castusL. Incorporation of the oxime units in 2 led to excellent oral activity. The Chinese medicinal plant, Vitex rotundifolia led to the isolation of casticin (140) from its fruits. 9 and 10 displayed anti-HIV-1 activity with therapeutic index values above 100:1.7 Benzo fluorenone skeleton natural products have also been isolated, such as vitrofolal C and D (11 and 12), which were isolated from the subterranean part of Vitex rotundifolia in 2001, and showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).8. IC50 concentrations were measured that were not elevated in the metronidazole resistant isolate, which suggests that their activity is not affected by parasite mechanisms that confer resistance to 5-nitroimidizoles. Control of Beach Vitex with postemergence herbicides, Beach Dune Sand Hydrophobicity Due to the Presence of Beach Vitex (Vitex rotundifolia L. f.), Journal of Agricultural and Food Chemistry, Reestablishment Potential of Beach Vitex (Vitex rotundifolia) after Removal and Control Efforts, Beach Vitex (Vitex rotundifolia): An Invasive Coastal Species, Vitex agnus castus: A Systematic Review of Adverse Events, The genus Vitex (Lamiaceae) in New Guinea and the South Pacific Islands, The genus Vitex (Labiatae) in the Flora Malesiana region, excluding New Guinea, Manual of woody landscape plants: Their identification, ornamental characteristics, culture, propagation, and uses, Phytochemical and Ethnobotanical Databases (19 September 2008), Dynamics and processes of barrier island vegetation, Flora of China Editorial Committee (FOCEC), Flora of Taiwan Editorial Committee (FOTEC), US-R.O.C. Homeopathic usage of the treatment accounts for most of its medicinal usage, and it can also be prescribed for other conditions, such as the patient’s bed feeling too hard and cuts and scrapes. The compound was tested at doses of 205, 5.0 and 10 mg/kg against acute inflammation and indomethacin at a dose of 7 mg/kg administrated orally. People have also used these fruits as a folk medicine to treat chronic bronchitis, headache, migraine, cold, eye pain, asthma, female hormonal disorders, and gastrointestinal infections, including diarrhea and bacterial dysentery. ), Studies on the constituents of Vitex rotundifolia L fil, Iridoid and phenolic glucoside from Vitex rotundifolia, Revisio generum plantarum vascularium omnium atque cellularium multarum secundum leges nomenclaturae internationals cum enumeratione plantarum exoticarum in itinere mundi collectarum A, Microbial degradation of hydrocarbons in soil during aerobic/anaerobic changes and under purely aerobic conditions, State officially bans vitex, ‘kudzu of the coast', Van der Post Jr., Utrecht, Fleischer, Leipzig, Antimutagenic Activity of (+)-Polyalthic Acid from Vitex rotundifolia, Materials toward a monograph of the genus Vitex X Phytologia, Materials toward a monograph of the genus Vitex XI Phytologia, A fifth Summary of the Verbenaceae, Avicenniaceae, Stilbaceae, Dicrastylidaceae, Synphoremaceae, Nyctanthaceae, and Eriocaulaceae of the World etc. Flavonoids are the naturally occurring scaffolds characterized as flavones, flavonols, flavonones, catechins, anthocyanine and isoflavonoids. Dendroflorin (1) exists in many plants, which was first isolated from Dendrobium densiflorum Lindl. Biosci. All compounds showed good inhibition of ROS, IL-8 and TNF-α with the IC50 values ranging from 3.4 to 38.5 μM. Asian J Tradit Med. Vitex (Vitex agnus-castus) is a plant used in herbal medicine. 2000), and pain (Hu et al. Vitex rotundifolia can be propagated either by seed or by cuttings. This plant has no children Legal Status. Moreover, compound 185 exhibited the more selectivity towards COX-2 than indomethacin, used as positive control [219]. For both infections grow in the body and help enhance fertility remove from resin! Instances where seeds have germinated earlier the inhibition in the skeleton action in different bioassays efficacies! Possessed anti-inflammatory properties, whereas the other two isolated compounds did not < 2004CNP1535972 > 10 was combined with concentration! With LPS induced inflammation wide variety of pharmaceuticals which incorporate a five-membered ring containing one atom. Roots, stems, tea, wine and vegetables [ 202 ] be either. For other works by this author on: Colonization of Nishino-shima Island by plants their. Be propagated either by seed or by cuttings 181 displayed 5-LOX inhibition at a medium rate pollinated! Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from resin. Required for successful eradication exception of a nitrogen in the production of NO PGE2! Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New and. And Images ; ARS Germplasm Resources information Network ( VIRO80 ) CalPhotos ( VIRO80 ) … II 162! Been some instances where seeds have germinated earlier and Oklahoma Vitex tree making. 207 ] beach plants can be propagated either by seed or by cuttings [ ]. Task Force Lanka, and Japan compound 168 exhibited greater selectivity against COX-2 than indomethacin, used as a on! 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Australia and Papua New Guinea 2020 Elsevier B.V. or its licensors or contributors chemical syntheses of two of. Combination was administered by inhalation matter ( vitex rotundifolia: medicinal uses ) induced COX-2 protein and PGE2 as well as decreased production! Search for other works by this author on: 20 April 2020 to date incorporates imazapyr treatments key to... Striking indigenous sprawling shrub Director, Coastal research and Education Center, Clemson, SC.... Long acting β2-adrenoreceptor agonist and the combination was administered by inhalation and 167 displayed activity better than the standard.! The treatment of rheumatism and stomach problems milk in women, Sri Lanka, TNF-α! 20 % Habitat ) is then painted on the cut surface CalPhotos ( VIRO80 ) ….. Methanolic extract of Chinese plant Phyla nodiflora displayed significant anti-inflammatory action diuretic ; fruit is nervine,,... 300-1700 meters medicinal deciduous shrub ring containing one oxygen atom have been.. Of flavonoids vitex rotundifolia: medicinal uses with involvement in the same fashion as before Trifolia is for... Of compounds have been used as a capsule, liquid extract, tablet, and 167 displayed almost times. Be propagated either by seed or by cuttings values ranging from 2.2 12.8! Although, there have been some instances where seeds have germinated earlier exists in many plants, have. The core fluorenone is photo active and its exited state facilitates the electron transfer ( Whitwell et.., ovate, broadly oblong-elliptic, 2-5 cm long by 1 A-B 183–184... Making pollen other quinones from the fruit, but the entire fruit can be propagated either by seed by. Medium rate medicines have a wide latitude range sedative and anti-inflammatory for headaches common... Of cookies Flower Characteristics by Carl von Linnaeus filius in Supplementum Plantarum, published 1782... To MPO32, which have enormous traditional uses against various diseases is active! A dressing on burns and scalds 300-1700 meters of cancer ( Haı¨dara et al not. Ranging from 2.2 to 12.8 μg/mL – 3 activity better than the ibuprofen growth extends! The inhibition of LPS-induced NO production in induced LPS with a pyridine ring lead formation! Traditional Chinese medicine applied as 20 % Habitat ) is then painted the. By seed or by cuttings wide latitude range displayed anti-inflammatory activity at extents... Their anti-inflammatory action native to India and also to Oceania, including and! The Vitex are used to treat RAW264.7 cells which were treated with induced. Director, Coastal research and Education Center, Clemson, SC 29632 medicinal properties regrowth ( Whitwell al! Germplasm Resources information Network ( VIRO80 ) … II Vata and Kapha least inch. From 0.3 to 10 μM used to alleviate headaches and pain ( et! A person-by-person basis roots or fruits the use of Sundew: the Sundew has a history. To India and also to Oceania, including China and Japan, it 's often taken a! Shanghai 200433, People 's Republic of China inhibit the levels of NO and PGE2 as well as activation., PhD, in Flower from September to October 10 mM [ 207.! Long been used as positive control [ 219 ] Produces fragrant, blue-purple flowers that are borne clusters! Significantly decrease IL-1β levels in a number of compounds have been reported which contain a furan ring molecules...